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dc.contributor.author
Ciro, Yhor
dc.contributor.author
Rojas, John
dc.contributor.author
Di Virgilio, Ana Laura
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dc.contributor.author
Alhajj, Maria J.
dc.contributor.author
Carabali, Gustavo A.
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Salamanca, Constain H.
dc.date.available
2021-10-14T16:27:36Z
dc.date.issued
2020-09-01
dc.identifier.citation
Ciro, Yhor; Rojas, John; Di Virgilio, Ana Laura; Alhajj, Maria J.; Carabali, Gustavo A.; et al.; Production, physicochemical characterization, and anticancer activity of methotrexate-loaded phytic acid-chitosan nanoparticles on HT-29 human colon adenocarcinoma cells; Elsevier; Carbohydrate Polymers; 243; 01-9-2020; 1-9
dc.identifier.issn
0144-8617
dc.identifier.uri
http://hdl.handle.net/11336/143623
dc.description.abstract
Methotrexate-loaded phytic acid-chitosan nanoparticles were synthesized by ionic gelation assisted by high-intensity sonication. The nanoparticles were characterized by particle size, polydispersity index, zeta potential (ZP) and encapsulation efficiency. Their physical stability was evaluated at 4 °C and 40 °C, whereas the in-vitro methotrexate release was assessed at pH 7.4. The data were heuristically fit to first-order, Higuchi, Peppas-Sahlin and Korsmeyer-Peppas models of release kinetics. Anticancer activity was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay on HT-29 human colon adenocarcinoma cells. Physicochemical analysis showed that the nanoparticles presented positive ZP values, sizes less than <300 nm and low polydispersity, except for systems formed with low amplitude sonication. The nanoparticles exhibited an adequate physical stability and a capability to modify methotrexate release by a non-Fickian mechanism, resulting in a more pronounced cytotoxic effect than the free drug on HT-29 human colon adenocarcinoma cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTICANCER
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CHITOSAN
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IONIC GELATION
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METHOTREXATE
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NANOPARTICLES
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PHYTIC ACID
dc.subject.classification
Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
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dc.subject.classification
Biotecnología Industrial
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Production, physicochemical characterization, and anticancer activity of methotrexate-loaded phytic acid-chitosan nanoparticles on HT-29 human colon adenocarcinoma cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-08-20T19:58:14Z
dc.identifier.eissn
1879-1344
dc.journal.volume
243
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ciro, Yhor. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Rojas, John. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Di Virgilio, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
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Fil: Alhajj, Maria J.. Universidad ICESI; Colombia
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Fil: Carabali, Gustavo A.. Universidad ICESI; Colombia
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Fil: Salamanca, Constain H.. Universidad ICESI; Colombia
dc.journal.title
Carbohydrate Polymers
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S014486172030610X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.carbpol.2020.116436
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