Mostrar el registro sencillo del ítem
dc.contributor.author
Folly, Mariany L. C.
dc.contributor.author
Ferreira, Gabriella F.
dc.contributor.author
Salvador, Maiara R.
dc.contributor.author
Sathler, Ana A.
dc.contributor.author
da Silva, Guilherme F.
dc.contributor.author
Santos, Joice Castelo Branco
dc.contributor.author
Santos, Julliana R. A. dos
dc.contributor.author
Nunes Neto, Wallace Ribeiro
dc.contributor.author
Rodrigues, João Francisco Silva
dc.contributor.author
Fernandes, Elizabeth Soares
dc.contributor.author
da Silva, Luís Cláudio Nascimento
dc.contributor.author
de Freitas, Gustavo José Cota
dc.contributor.author
Denadai, Ângelo M.
dc.contributor.author
Rodrigues, Ivanildes V.
dc.contributor.author
Mendonça, Leonardo M.
dc.contributor.author
Monteiro, Andrea Souza
dc.contributor.author
Santos, Daniel Assis
dc.contributor.author
Cabrera, Gabriela Myriam
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Siless, Gastón Ezequiel
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Lang, Karen L.
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2021-09-27T17:48:53Z
dc.date.issued
2020-02
dc.identifier.citation
Folly, Mariany L. C.; Ferreira, Gabriella F.; Salvador, Maiara R.; Sathler, Ana A.; da Silva, Guilherme F.; et al.; Evaluation of in vitro Antifungal Activity of Xylosma prockia (Turcz.) Turcz. (Salicaceae) Leaves Against Cryptococcus spp.; Frontiers Media; Frontiers in Microbiology; 10; 2-2020
dc.identifier.issn
1664-302X
dc.identifier.uri
http://hdl.handle.net/11336/141611
dc.description.abstract
Cryptococcus species are responsible for important systemic mycosis and are estimated to cause millions of new cases annually. The available therapy is limited due to the high toxicity and the increasing rates of yeast resistance to antifungal drugs. Popularly known as “sucará,” Xylosma prockia (Turcz.) Turcz. (Salicaceae) is a native plant from Brazil with little information on its pharmacological potential. In this work, we evaluated in vitro anticryptococcal effects of the leaf ethanolic extract of X. prockia and its fractions against Cryptococcus gattii and Cryptococcus neoformans. We also evaluated phenotypic alterations caused by ethyl acetate fraction (EAF) (chosen according to its biological results). The liquid chromatography–mass spectrometry (LC-MS) analysis of EAF demonstrated the presence of phenolic metabolites that belong to three structurally related groups as majority compounds: caffeoylquinic acid, coumaroyl-glucoside, and caffeoyl-glucoside/deoxyhexosyl-caffeoyl glucoside derivatives. The minimum inhibitory concentration (MIC) values against C. gattii and C. neoformans ranged from 8 to 64 mg/L and from 0.5 to 8 mg/L, for ethanolic extract and EAF, respectively. The EAF triggered an oxidative burst and promoted lipid peroxidation. EAF also induced a reduction of ergosterol content in the pathogen cell membrane. These effects were not associated with alterations in the cell surface charge or in the thermodynamic fingerprint of the molecular interaction between EAF and the yeasts evaluated. Cytotoxic experiments with peripheral blood mononuclear cells (PBMCs) demonstrated that EAF was more selective for yeasts than was PBMCs. The results may provide evidence that X. prockia leaf extract might indeed be a potential source of antifungal agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIFUNGAL AGENTS
dc.subject
BIODIVERSITY
dc.subject
CRYPTOCOCCUSSPP
dc.subject
NATURAL PRODUCTS
dc.subject
XYLOSMA PROCKIA
dc.subject.classification
Otras Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Evaluation of in vitro Antifungal Activity of Xylosma prockia (Turcz.) Turcz. (Salicaceae) Leaves Against Cryptococcus spp.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:58:23Z
dc.journal.volume
10
dc.journal.pais
Suiza
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Folly, Mariany L. C.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: Ferreira, Gabriella F.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: Salvador, Maiara R.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: Sathler, Ana A.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: da Silva, Guilherme F.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: Santos, Joice Castelo Branco. Ceuma University; Brasil
dc.description.fil
Fil: Santos, Julliana R. A. dos. Ceuma University; Brasil
dc.description.fil
Fil: Nunes Neto, Wallace Ribeiro. Ceuma University; Brasil
dc.description.fil
Fil: Rodrigues, João Francisco Silva. Ceuma University; Brasil
dc.description.fil
Fil: Fernandes, Elizabeth Soares. Ceuma University; Brasil
dc.description.fil
Fil: da Silva, Luís Cláudio Nascimento. Ceuma University; Brasil
dc.description.fil
Fil: de Freitas, Gustavo José Cota. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Denadai, Ângelo M.. Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas; Brasil
dc.description.fil
Fil: Rodrigues, Ivanildes V.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: Mendonça, Leonardo M.. Universidade Federal de Juiz de Fora; Brasil
dc.description.fil
Fil: Monteiro, Andrea Souza. Ceuma University; Brasil
dc.description.fil
Fil: Santos, Daniel Assis. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
dc.description.fil
Fil: Siless, Gastón Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
dc.description.fil
Fil: Lang, Karen L.. Universidade Federal de Juiz de Fora; Brasil
dc.journal.title
Frontiers in Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fmicb.2019.03114/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmicb.2019.03114
Archivos asociados