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dc.contributor.author
Yu, Leqian
dc.contributor.author
Wei, Yulei
dc.contributor.author
Sun, Hai Xi
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Mahdi, Ahmed K.
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Pinzon Arteaga, Carlos A.
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Sakurai, Masahiro
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Schmitz, Daniel A.
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Zheng, Canbin
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Ballard, Emily D.
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Li, Jie
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Tanaka, Noriko
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Kohara, Aoi
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Okamura, Daiji
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Mutto, Adrián Angel
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dc.contributor.author
Gu, Ying
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Ross, Pablo J.
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Wu, Jun
dc.date.available
2021-09-17T15:43:40Z
dc.date.issued
2021-03
dc.identifier.citation
Yu, Leqian; Wei, Yulei; Sun, Hai Xi; Mahdi, Ahmed K.; Pinzon Arteaga, Carlos A.; et al.; Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification; Cell Press; Cell Stem Cell; 28; 3; 3-2021; 550-567.e12
dc.identifier.issn
1934-5909
dc.identifier.uri
http://hdl.handle.net/11336/140711
dc.description.abstract
Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency continuum in vivo. Previous studies have generated a number of PSCs with distinct properties. To date, however, no known PSCs have demonstrated dual competency for chimera formation and direct responsiveness to primordial germ cell (PGC) specification, a unique functional feature of formative pluripotency. Here, by modulating fibroblast growth factor (FGF), transforming growth factor β (TGF-β), and WNT pathways, we derived PSCs from mice, horses, and humans (designated as XPSCs) that are permissive for direct PGC-like cell induction in vitro and are capable of contributing to intra- or inter-species chimeras in vivo. XPSCs represent a pluripotency state between naive and primed pluripotency and harbor molecular, cellular, and phenotypic features characteristic of formative pluripotency. XPSCs open new avenues for studying mammalian pluripotency and dissecting the molecular mechanisms governing PGC specification. Our method may be broadly applicable for the derivation of analogous stem cells from other mammalian species. Yu, Wu, and colleagues report the derivation of intermediate PSCs from mice, horses, and humans (designated as XPSCs) that are permissive for direct PGC-like cell induction in vitro and capable of contributing to intra- or inter-species chimeras in vivo. XPSCs harbor molecular, cellular, and phenotypic features characteristic of formative pluripotency.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHIMERAS
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FORMATIVE PLURIPOTENCY
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HORSE EMBRYONIC STEM CELLS
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INDUCED PLURIPOTENT STEM CELLS
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INTERMEDIATE PLURIPOTENT STEM CELLS
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INTERSPECIES CHIMERAS
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PLURIPOTENCY
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PRIMORIDIAL GERM CELLS
dc.subject.classification
Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-08-25T19:41:15Z
dc.journal.volume
28
dc.journal.number
3
dc.journal.pagination
550-567.e12
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Yu, Leqian. University of Texas Southwestern Medical Center; Estados Unidos
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Fil: Wei, Yulei. University of Texas Southwestern Medical Center; Estados Unidos
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Fil: Sun, Hai Xi. No especifíca;
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Fil: Mahdi, Ahmed K.. University of California; Estados Unidos
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Fil: Pinzon Arteaga, Carlos A.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Sakurai, Masahiro. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Schmitz, Daniel A.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Zheng, Canbin. University of Texas Southwestern Medical Center; Estados Unidos
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Fil: Ballard, Emily D.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Li, Jie. No especifíca;
dc.description.fil
Fil: Tanaka, Noriko. Kindai University; Japón
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Fil: Kohara, Aoi. Kindai University; Japón
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Fil: Okamura, Daiji. Kindai University; Japón
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Fil: Mutto, Adrián Angel. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
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Fil: Gu, Ying. No especifíca;
dc.description.fil
Fil: Ross, Pablo J.. University of California; Estados Unidos
dc.description.fil
Fil: Wu, Jun. University of Texas Southwestern Medical Center; Estados Unidos
dc.journal.title
Cell Stem Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.stem.2020.11.003
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