Artículo
Lignans and gut microbiota: An interplay revealing potential health implications
Senizza, Alice; Rocchetti, Gabriele; Mosse, Juana Inés
; Patrone, Vania; Callegari, Maria Luisa; Morelli, Lorenzo; Lucini, Luigi
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
12/2020
Editorial:
Molecular Diversity Preservation International
Revista:
Molecules
ISSN:
1420-3049
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis.
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Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Senizza, Alice; Rocchetti, Gabriele; Mosse, Juana Inés; Patrone, Vania; Callegari, Maria Luisa; et al.; Lignans and gut microbiota: An interplay revealing potential health implications; Molecular Diversity Preservation International; Molecules; 25; 23; 12-2020; 1-17
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