Artículo

Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents

Suvire, Fernando Daniel; Sortino, Maximiliano AndrésIcon ; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; Cruz, Uriel Mora; Enriz, Ricardo DanielIcon
Fecha de publicación: 15/03/2006
Editorial: Elsevier
Revista: Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
Palabras clave: ANTIFUNGAL ACTIVITY , HOMOALLYLAMINES , SAR , SYNTHESIS
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/138702
URL: http://www.sciencedirect.com/science/article/pii/S0968089605010230
DOI: http://dx.doi.org/10.1016/j.bmc.2005.10.036
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Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Suvire, Fernando Daniel; Sortino, Maximiliano Andrés; Kouznetsov, Vladimir V.; Vargas M, Leonor Y.; Zacchino, Susana Alicia Stella; et al.; Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents; Elsevier; Bioorganic & Medicinal Chemistry; 14; 6; 15-3-2006; 1851-1862
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