Structure-antifungal activity relationship of cinnamic acid derivatives

A structure-antifungal activity relationship (SAR) study of 22 related cinnamic acid derivatives was carried out. Attention was focused on the antifungal activities exhibited against Aspergillus flavus, Aspergillus terreus, and Aspergillus niger. (E)-3-(4-Methoxy-3-(3-methylbut-2-enyl)phenyl)acrylic acid (16) exhibited antifungal activity against A. niger, comparable to that of miconazole and a significant antifungal effect against A. flavus and A. terreus as well. A structure-activity relationship (SAR) study of related cinnamic acid derivatives has allowed a model to be proposed for the recognition of the minimal structural requirements for the antifungal effect in this series.

Palabras clave: ANTIFUNGAL , ASPERGILLOSIS , CINNAMIC ACID DERIVATIVES , STRUCTURE-ACTIVITY RELATIONSHIP

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/138701

URL: https://pubs.acs.org/doi/10.1021/jf0729098

DOI: http://dx.doi.org/10.1021/jf0729098

Colecciones

Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS

Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA

Articulos(INTEQUI)
Articulos de INST. DE INVEST. EN TECNOLOGIA QUIMICA

Citación

Bisogno, Fabricio Román; Mascotti, María Laura; Sanchez, Cecilia; Garibotto, Francisco Matías; Giannini, Fernando Angel; et al.; Structure-antifungal activity relationship of cinnamic acid derivatives; American Chemical Society; Journal of Agricultural and Food Chemistry; 55; 26; 26-12-2007; 10635-10640

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