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dc.contributor.author
White, Verónica
dc.contributor.author
Jawerbaum, Alicia Sandra
dc.contributor.author
Mazzucco, María Belén
dc.contributor.author
Gauster, Martin
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Desoye, Gernot
dc.contributor.author
Hiden, Ursula
dc.date.available
2017-03-14T20:56:58Z
dc.date.issued
2015-01
dc.identifier.citation
White, Verónica; Jawerbaum, Alicia Sandra; Mazzucco, María Belén; Gauster, Martin; Desoye, Gernot; et al.; Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats; Nature Publishing Group; Pediatric Research; 77; 1-1; 1-2015; 48-55
dc.identifier.issn
0031-3998
dc.identifier.uri
http://hdl.handle.net/11336/13857
dc.description.abstract
Background: Diabetes in pregnancy affects fetal growth and development. The insulin/insulin-like growth factors (IGF) system comprising insulin, IGF, their receptors, and binding proteins, has been implicated in fetal growth regulation. This study tested the hypothesis that maternal diabetes alters the fetal insulin/IGF system in a tissue-specific manner. Methods: Wistar rats were rendered diabetic by neonatal administration of streptozotocin and mated with control rats. At day 21 of gestation, the weights of fetuses, placentas, and fetal organs (heart, lung, liver, stomach, intestine, and pancreas) were determined. Maternal and fetal plasma concentrations of insulin, IGF1, and IGF2 were measured by ELISA, and expression of IGF1, IGF2, IGF1R, IGF2R, IR, IGFBP1, BP2, and BP3 in placenta and fetal organs by qPCR. Results: The well-known increase in fetal growth in this model of mild diabetes is accompanied by elevated insulin and IGF1 levels and alterations of the insulin/IGF system in the fetus and the placenta. These alterations were organ and gene specific. The insulin/IGF system was generally upregulated, especially in the fetal heart, while it was downregulated in fetal lung. Conclusion: In our model of mild diabetes, the effect of maternal diabetes on fetal weight and fetal insulin/IGF system expression is organ specific with highly sensitive organs such as lung and heart, and organs that were less affected, such as stomach.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Maternal Diabetes
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Fetus
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Placenta
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Insulin-Igf
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Pregnancy
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Biología Reproductiva
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-09T15:06:36Z
dc.identifier.eissn
1530-0447
dc.journal.volume
77
dc.journal.number
1-1
dc.journal.pagination
48-55
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: White, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Mazzucco, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Gauster, Martin. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
dc.description.fil
Fil: Desoye, Gernot. Medical University of Graz. Department of Obstetrics and Gynaecology; Austria
dc.description.fil
Fil: Hiden, Ursula. Medical University of Graz. Department of Obstetrics and Gynaecology; Austria
dc.journal.title
Pediatric Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/pr/journal/v77/n1-1/full/pr2014139a.html#affil-auth
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/pr.2014.139
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