Artículo
Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats
White, Verónica
; Jawerbaum, Alicia Sandra
; Mazzucco, María Belén
; Gauster, Martin; Desoye, Gernot; Hiden, Ursula
Fecha de publicación:
01/2015
Editorial:
Nature Publishing Group
Revista:
Pediatric Research
ISSN:
0031-3998
e-ISSN:
1530-0447
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Diabetes in pregnancy affects fetal growth and development. The insulin/insulin-like growth factors (IGF) system comprising insulin, IGF, their receptors, and binding proteins, has been implicated in fetal growth regulation. This study tested the hypothesis that maternal diabetes alters the fetal insulin/IGF system in a tissue-specific manner. Methods: Wistar rats were rendered diabetic by neonatal administration of streptozotocin and mated with control rats. At day 21 of gestation, the weights of fetuses, placentas, and fetal organs (heart, lung, liver, stomach, intestine, and pancreas) were determined. Maternal and fetal plasma concentrations of insulin, IGF1, and IGF2 were measured by ELISA, and expression of IGF1, IGF2, IGF1R, IGF2R, IR, IGFBP1, BP2, and BP3 in placenta and fetal organs by qPCR. Results: The well-known increase in fetal growth in this model of mild diabetes is accompanied by elevated insulin and IGF1 levels and alterations of the insulin/IGF system in the fetus and the placenta. These alterations were organ and gene specific. The insulin/IGF system was generally upregulated, especially in the fetal heart, while it was downregulated in fetal lung. Conclusion: In our model of mild diabetes, the effect of maternal diabetes on fetal weight and fetal insulin/IGF system expression is organ specific with highly sensitive organs such as lung and heart, and organs that were less affected, such as stomach.
Palabras clave:
Maternal Diabetes
,
Fetus
,
Placenta
,
Insulin-Igf
,
Pregnancy
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Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
White, Verónica; Jawerbaum, Alicia Sandra; Mazzucco, María Belén; Gauster, Martin; Desoye, Gernot; et al.; Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats; Nature Publishing Group; Pediatric Research; 77; 1-1; 1-2015; 48-55
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