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dc.contributor.author Helbling, Ignacio Marcelo
dc.contributor.author Cabrera, Maria Ines
dc.contributor.author Luna, Julio Alberto
dc.date.available 2017-02-24T13:53:59Z
dc.date.issued 2011-08
dc.identifier.citation Helbling, Ignacio Marcelo; Cabrera, Maria Ines; Luna, Julio Alberto; Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance; Elsevier Science; European Journal Of Pharmaceutical Sciences; 44; 3; 8-2011; 288-298
dc.identifier.issn 0928-0987
dc.identifier.uri http://hdl.handle.net/11336/13352
dc.description.abstract A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torusshaped systems in where the initial load of drug is higher than its solubility in the polymer.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject VAGINAL RING
dc.subject PSEUDO-STEADY STATE APPROXIMATION
dc.subject MASS TRANSFER RESISTANCE
dc.subject MATHEMATICAL MODELING
dc.subject MOVING FRONT
dc.subject DRUG DELIVERY
dc.subject.classification Otras Ingeniería Química
dc.subject.classification Ingeniería Química
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-17T13:26:07Z
dc.journal.volume 44
dc.journal.number 3
dc.journal.pagination 288-298
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
dc.description.fil Fil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
dc.description.fil Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
dc.journal.title European Journal Of Pharmaceutical Sciences
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S092809871100265X
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejps.2011.08.008


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)