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Artículo

Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance

Helbling, Ignacio MarceloIcon ; Cabrera, Maria InesIcon ; Luna, Julio AlbertoIcon
Fecha de publicación: 08/2011
Editorial: Elsevier Science
Revista: European Journal Of Pharmaceutical Sciences
ISSN: 0928-0987
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ingeniería Química

Resumen

A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torusshaped systems in where the initial load of drug is higher than its solubility in the polymer.
Palabras clave: Vaginal Ring , Pseudo-Steady State Approximation , Mass Transfer Resistance , Mathematical Modeling , Moving Front , Drug Delivery
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/13352
URL: http://www.sciencedirect.com/science/article/pii/S092809871100265X
DOI: http://dx.doi.org/10.1016/j.ejps.2011.08.008
Colecciones
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Helbling, Ignacio Marcelo; Cabrera, Maria Ines; Luna, Julio Alberto; Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance; Elsevier Science; European Journal Of Pharmaceutical Sciences; 44; 3; 8-2011; 288-298
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