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dc.contributor.author
Teixeira Pinheiro, Leandro C.
dc.contributor.author
Toledo, Maria Fernanda
dc.contributor.author
Nascimento dos Santos, Gabriel
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Mendez Otero, Rosalia
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Mesentier Louro, Louise A.
dc.contributor.author
Santiago, Marcelo F.
dc.date.available
2021-05-13T12:04:21Z
dc.date.issued
2020-11
dc.identifier.citation
Teixeira Pinheiro, Leandro C.; Toledo, Maria Fernanda; Nascimento dos Santos, Gabriel; Mendez Otero, Rosalia; Mesentier Louro, Louise A.; et al.; Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro; Elsevier; Experimental Eye Research; 200; 11-2020; 108212- 108212
dc.identifier.issn
0014-4835
dc.identifier.uri
http://hdl.handle.net/11336/131951
dc.description.abstract
Cellular therapy with mesenchymal stem cells (MSC) is emerging as an effective option to treat optic neuropathies. In models of retinal degeneration, MSC injected in the vitreous body protects injured retinal ganglion cells and stimulate their regeneration, however the mechanism is still unknown. Considering the immunomodulating proprieties of MSC and the controversial role of microglial contribution on retinal regeneration, we developed an in vitro co-culture model to analyze the effect of MSC on retinal microglia population.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CELLULAR THERAPY
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MESENCHYMAL STEM CELL
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MICROGLIA
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RETINA
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RETINAL GANGLION CELL
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-22T20:05:49Z
dc.journal.volume
200
dc.journal.pagination
108212- 108212
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Teixeira Pinheiro, Leandro C.. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa; Brasil
dc.description.fil
Fil: Toledo, Maria Fernanda. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Nascimento dos Santos, Gabriel. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Mendez Otero, Rosalia. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa; Brasil
dc.description.fil
Fil: Mesentier Louro, Louise A.. University of Stanford; Estados Unidos. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Santiago, Marcelo F.. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa; Brasil
dc.journal.title
Experimental Eye Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://www.sciencedirect.com/science/article/abs/pii/S001448352030470X?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.exer.2020.108212
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