Artículo

Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro

Teixeira Pinheiro, Leandro C.; Toledo, Maria FernandaIcon ; Nascimento dos Santos, Gabriel; Mendez Otero, Rosalia; Mesentier Louro, Louise A.; Santiago, Marcelo F.
Fecha de publicación: 11/2020
Editorial: Elsevier
Revista: Experimental Eye Research
ISSN: 0014-4835
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Cellular therapy with mesenchymal stem cells (MSC) is emerging as an effective option to treat optic neuropathies. In models of retinal degeneration, MSC injected in the vitreous body protects injured retinal ganglion cells and stimulate their regeneration, however the mechanism is still unknown. Considering the immunomodulating proprieties of MSC and the controversial role of microglial contribution on retinal regeneration, we developed an in vitro co-culture model to analyze the effect of MSC on retinal microglia population.
Palabras clave: CELLULAR THERAPY , MESENCHYMAL STEM CELL , MICROGLIA , RETINA , RETINAL GANGLION CELL
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/131951
DOI: https://www.sciencedirect.com/science/article/abs/pii/S001448352030470X?via%3Dih
URL: http://dx.doi.org/10.1016/j.exer.2020.108212
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Teixeira Pinheiro, Leandro C.; Toledo, Maria Fernanda; Nascimento dos Santos, Gabriel; Mendez Otero, Rosalia; Mesentier Louro, Louise A.; et al.; Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro; Elsevier; Experimental Eye Research; 200; 11-2020; 108212- 108212
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