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dc.contributor.author
Sortino, Maximiliano Andrés  
dc.contributor.author
Cechinel Filho, Valdir  
dc.contributor.author
Zacchino, Susana Alicia Stella  
dc.date.available
2021-04-28T11:51:54Z  
dc.date.issued
2009-05  
dc.identifier.citation
Sortino, Maximiliano Andrés; Cechinel Filho, Valdir; Zacchino, Susana Alicia Stella; Highly enantioselective reduction of the C-C double bond of N-phenyl-2-methyl- and N-phenyl-2,3-dimethyl-maleimides by fungal strains; Pergamon-Elsevier Science Ltd; Tetrahedron: Asymmetry; 20; 5-2009; 1106-1108  
dc.identifier.issn
0957-4166  
dc.identifier.uri
http://hdl.handle.net/11336/130936  
dc.description.abstract
The CAC double bond of non-substituted and substituted maleimides were hydrogenated to the corresponding succinimides by fungal strains. 2- and 2,3-methylated-phenyl-maleimides were enantioselectively reduced to (R)-N-phenyl-3-methylsuccinimide and to trans-(R,R)-N-phenyl-2,3-dimethylsuccinimide respectively by Aspergillus niger, A. flavus and A. fumigatus (conversion 96 to 99%), Fusarium graminearum and Penicillium sp (conversion: 37 and 39%), with 99% ee.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
enantioselective reduction  
dc.subject
Biotransformation  
dc.subject.classification
Química Orgánica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Highly enantioselective reduction of the C-C double bond of N-phenyl-2-methyl- and N-phenyl-2,3-dimethyl-maleimides by fungal strains  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-07-22T15:43:10Z  
dc.journal.volume
20  
dc.journal.pagination
1106-1108  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Cechinel Filho, Valdir. University of the Itajaí Valley; Brasil  
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina  
dc.journal.title
Tetrahedron: Asymmetry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0957416609003255?via%3Dihub  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tetasy.2009.04.009  

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