Artículo

Highly enantioselective reduction of the C-C double bond of N-phenyl-2-methyl- and N-phenyl-2,3-dimethyl-maleimides by fungal strains

Sortino, Maximiliano AndrésIcon ; Cechinel Filho, Valdir; Zacchino, Susana Alicia Stella
Fecha de publicación: 05/2009
Editorial: Pergamon-Elsevier Science Ltd
Revista: Tetrahedron: Asymmetry
ISSN: 0957-4166
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The CAC double bond of non-substituted and substituted maleimides were hydrogenated to the corresponding succinimides by fungal strains. 2- and 2,3-methylated-phenyl-maleimides were enantioselectively reduced to (R)-N-phenyl-3-methylsuccinimide and to trans-(R,R)-N-phenyl-2,3-dimethylsuccinimide respectively by Aspergillus niger, A. flavus and A. fumigatus (conversion 96 to 99%), Fusarium graminearum and Penicillium sp (conversion: 37 and 39%), with 99% ee.
Palabras clave: enantioselective reduction , Biotransformation
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/130936
URL: https://www.sciencedirect.com/science/article/abs/pii/S0957416609003255?via%3Dih
DOI: http://dx.doi.org/10.1016/j.tetasy.2009.04.009
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Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Sortino, Maximiliano Andrés; Cechinel Filho, Valdir; Zacchino, Susana Alicia Stella; Highly enantioselective reduction of the C-C double bond of N-phenyl-2-methyl- and N-phenyl-2,3-dimethyl-maleimides by fungal strains; Pergamon-Elsevier Science Ltd; Tetrahedron: Asymmetry; 20; 5-2009; 1106-1108
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