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dc.contributor.author
Rumi, María Valeria
dc.contributor.author
Mas, Javier
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Elena, Alan Xavier
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Cerdeira, Louise
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Muñoz, Maria E.
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Lincopan, Nilton
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Gentilini, Élida R.
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Di Conza, José Alejandro
dc.contributor.author
Gutkind, Gabriel Osvaldo
dc.date.available
2021-04-12T12:14:05Z
dc.date.issued
2019-03
dc.identifier.citation
Rumi, María Valeria; Mas, Javier; Elena, Alan Xavier; Cerdeira, Louise; Muñoz, Maria E.; et al.; Co-occurrence of clinically relevant β-lactamases and MCR-1 encoding genes in Escherichia coli from companion animals in Argentina; Elsevier Science; Veterinary Microbiology; 230; 3-2019; 228-234
dc.identifier.issn
0378-1135
dc.identifier.uri
http://hdl.handle.net/11336/129812
dc.description.abstract
Extended-spectrum β-lactamase (ESBL), plasmid-mediated AmpC (pAmpC) and MCR-1 phosphoethanolamine transferase enzymes have been pointed out as the main plasmid-mediated mechanisms of resistance to third generation cephalosporins (TGC) and colistin, respectively, and are currently considered a major concern both in human and veterinary medicine. Little data on these resistance determinants prevalence in companion animal infections is available. The aim of this study was to determine the resistance profile of Escherichia coli isolated from pet infections, in Argentina, and to characterize the resistance mechanisms to TGC, as well as the presence of the plasmid-borne colistin resistance gene, mcr-1. A total of 54 E. coli isolates were collected from clinical samples in dogs and cats; from them, 20/54 (37%, CI 95: [24%; 51%]) displayed resistance to TGC. In this regard, thirteen pAmpC-producing isolates were positive for bla CMY-2 genes, whereas seven ESBL- producers harboured bla CTX-M-2 (n = 4), bla CTX-M-15 (n = 2) and bla CTX-M-14 (n = 1) genes. One E. coli strain (V80), isolated from a canine urinary tract infection, showed resistance to colistin (MIC = 8 μg/ml) and whole-genome sequencing analysis revealed co-occurrence of mcr-1.1, bla CTX-M-2 , aadA1, ant(2′')-Ia, catA1 and sul1 genes; the former being carried by a 60,587-bp IncI2 plasmid, previously reported in human colistin-resistant E. coli. E. coli V80 belonged to ST770 and the highly virulent phylogenetic group B2. In general, most of these multidrug-resistant isolates belonged to the phylogenetic group F (11/20) and to a lesser extent B2 (5/20), B1 (2/20), D (1/20) and E (1/20). In summary, CMY- and CTX-M-type β-lactamases may constitute the main TGC resistance mechanism in E. coli isolated from pet infections in Argentina, whereas dissemination of colistin resistance mechanism MCR-1 in the human-animal interface has been mediated by IncI2 plasmids.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIBIOTIC RESISTANCE
dc.subject
CMY-2
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CTX-M
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ESBL
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INCI2
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MCR-1
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PAMPC
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PETS
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SOUTH AMERICA
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Co-occurrence of clinically relevant β-lactamases and MCR-1 encoding genes in Escherichia coli from companion animals in Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T20:00:33Z
dc.journal.volume
230
dc.journal.pagination
228-234
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Rumi, María Valeria. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Mas, Javier. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Elena, Alan Xavier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
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Fil: Cerdeira, Louise. Universidade de Sao Paulo; Brasil
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Fil: Muñoz, Maria E.. Universidade de Sao Paulo; Brasil
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Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Gentilini, Élida R.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Di Conza, José Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Veterinary Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378113518311829
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vetmic.2019.02.006
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