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dc.contributor.author
Buchet, Delphine  
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Garcia, Corina Ileana  
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Deboux, Cyrille  
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Nait Oumesmar, Brahim  
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Baron Van Evercooren, Anne  
dc.date.available
2017-02-13T19:38:33Z  
dc.date.issued
2011-04  
dc.identifier.citation
Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne; Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord; Oxford University Press; Brain; 134; 4; 4-2011; 1168-1183  
dc.identifier.issn
0006-8950  
dc.identifier.uri
http://hdl.handle.net/11336/12921  
dc.description.abstract
Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Oxford University Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Human Neural Progenitor Cells  
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Oligodendrocyte  
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Migration  
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Oligodendrogenesis  
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Remyelination  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-02-09T18:23:19Z  
dc.journal.volume
134  
dc.journal.number
4  
dc.journal.pagination
1168-1183  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Oxford  
dc.description.fil
Fil: Buchet, Delphine. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia  
dc.description.fil
Fil: Garcia, Corina Ileana. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Deboux, Cyrille. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia  
dc.description.fil
Fil: Nait Oumesmar, Brahim. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia  
dc.description.fil
Fil: Baron Van Evercooren, Anne. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia  
dc.journal.title
Brain  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awr030  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/brain/awr030