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Artículo

Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord

Buchet, Delphine; Garcia, Corina IleanaIcon ; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne
Fecha de publicación: 04/2011
Editorial: Oxford University Press
Revista: Brain
ISSN: 0006-8950
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.
Palabras clave: Human Neural Progenitor Cells , Oligodendrocyte , Migration , Oligodendrogenesis , Remyelination
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/12921
URL: https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awr030
DOI: https://doi.org/10.1093/brain/awr030
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne; Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord; Oxford University Press; Brain; 134; 4; 4-2011; 1168-1183
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