Artículo
Acute body sodium depletion induces skin sodium mobilization in female Wistar rats
Lopes-Menezes, V. C.; Dos-Santos, R. C.; Felintro, V.; Monteiro, L. R. N.; Paes-Leme, B.; Lustrino, D.; Casartelli, Marina Paola
; Vivas, Laura Marta
; Mecawi, Andre Souza; Reis, L. C.
Fecha de publicación:
12/2019
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Experimental Physiology
ISSN:
0958-0670
e-ISSN:
1469-445X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Oestradiol, which is an important hormone for water and electrolyte balance, also has a role in the inhibition of induced Na+ appetite. Sodium can be stored in the skin in osmotically active or inactive forms, and this skin Na+ reservoir may be involved in the control of body Na+ levels during physiopathological challenges. In this study, we investigated whether the effect of sodium depletion by frusemide can mobilize Na+ from the skin reservoir and whetheroestradiol replacement changes or mobilizes theNa+ reserves in the skin. Ovariectomized Wistar rats were treated with vehicle or oestradiol for 7 days to evaluate the effects of oestrogen on the hydroelectrolyte balance, intake responses and skin Na+ and water content in basal conditions. Furthermore, the effects of oestrogen were evaluated after 24 h frusemide-inducedwhole-body Na+ depletion. Oestradiol-replaced rats exhibited reduced water intake without any significant changes in salt intake,Na+ excretion orwater andNa+ skin content in basal conditions.After sodium depletion, both vehicle- and oestradiol-treated rats exhibited an increase in the osmotically active skin Na+, which was associated with a decrease of the inactive skin Na+ reservoir. Oestrogen decreased the hypertonic saline intake induced by Na+ depletion, but it was not associated with any significant changes in the skin Na+ reservoir. Thus, sodium depletionis able to change the inactive?active skin Na+ reservoir balance. However, the oestrogenic modulation of sodium appetite after Na+ depletion is probably not related to the action of this hormone in the skin Na+ reservoir balance.
Palabras clave:
OESTRADIOL
,
SODIUM RESERVOIR
,
SODIUM DEPLETION
,
SKIN SODIUM RESERVOIR
Archivos asociados
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Identificadores
Colecciones
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Lopes-Menezes, V. C.; Dos-Santos, R. C.; Felintro, V.; Monteiro, L. R. N.; Paes-Leme, B.; et al.; Acute body sodium depletion induces skin sodium mobilization in female Wistar rats; Wiley Blackwell Publishing, Inc; Experimental Physiology; 104; 12; 12-2019; 1754-1761
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