Artículo
Pregnancy galectinology: Insights into a complex network of glycan binding proteins
Blois, Sandra M.; Dveksler, Gabriela; Vasta, Gerardo R.; Freitag, Nancy; Blanchard, Véronique; Barrientos, Gabriela Laura
Fecha de publicación:
05/2019
Editorial:
Frontiers Media S.A.
Revista:
Frontiers in Immunology
ISSN:
1664-3224
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.
Palabras clave:
GALECTINS
,
GLYCANS
,
PLACENTATION
,
PREECLAMPSIA
,
PREGNANCY
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Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Blois, Sandra M.; Dveksler, Gabriela; Vasta, Gerardo R.; Freitag, Nancy; Blanchard, Véronique; et al.; Pregnancy galectinology: Insights into a complex network of glycan binding proteins; Frontiers Media S.A.; Frontiers in Immunology; 10; MAY; 5-2019; 1-15
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