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dc.contributor.author
Podaza, Enrique Arturo  
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Sabbione, Florencia  
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Risnik, Denise Mariel  
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Borge, Mercedes  
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Almejún, María Belén  
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Colado, Ana  
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Fernández Grecco, Horacio  
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Cabrejo, María del Rosario  
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Bezares, Raimundo F.  
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Trevani, Analía Silvina  
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Gamberale, Romina  
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Giordano, Mirta Nilda  
dc.date.available
2021-03-18T21:11:01Z  
dc.date.issued
2016-10-28  
dc.identifier.citation
Podaza, Enrique Arturo; Sabbione, Florencia; Risnik, Denise Mariel; Borge, Mercedes; Almejún, María Belén; et al.; Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs); Springer; Cancer Immunology Immunotherapy; 66; 1; 28-10-2016; 77-89  
dc.identifier.issn
0340-7004  
dc.identifier.uri
http://hdl.handle.net/11336/128605  
dc.description.abstract
Chronic lymphocytic leukemia (CLL) is characterized by immune defects that contribute to a high rate of infections and autoimmune cytopenias. Neutrophils are the first line of innate immunity and respond to pathogens through multiple mechanisms, including the release of neutrophil extracellular traps (NETs). These web-like structures composed of DNA, histones, and granular proteins are also produced under sterile conditions and play important roles in thrombosis and autoimmune disorders. Here we show that neutrophils from CLL patients are more prone to release NETs compared to those from age-matched healthy donors (HD). Increased generation of NETs was not due to higher levels of elastase, myeloperoxidase, or reactive oxygen species production. Instead, we found that plasma from CLL patients was able to prime neutrophils from HD to generate higher amounts of NETs upon activation. Plasmatic IL-8 was involved in the priming effect since its depletion reduced plasma capacity to enhance NETs release. Finally, we found that culture with NETs delayed spontaneous apoptosis and increased the expression of activation markers on leukemic B cells. Our study provides new insights into the immune dysregulation in CLL and suggests that the chronic inflammatory environment typical of CLL probably underlies this inappropriate neutrophil priming.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CHRONIC LYMPHOCYTIC LEUKEMIA  
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INFECTIONS  
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INTERLEUKIN 8 (IL-8)  
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NEUTROPHIL  
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NEUTROPHIL EXTRACELLULAR TRAPS  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-12-22T15:42:27Z  
dc.journal.volume
66  
dc.journal.number
1  
dc.journal.pagination
77-89  
dc.journal.pais
Alemania  
dc.description.fil
Fil: Podaza, Enrique Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
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Fil: Sabbione, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
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Fil: Risnik, Denise Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
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Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
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Fil: Almejún, María Belén. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina  
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Fil: Colado, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
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Fil: Fernández Grecco, Horacio. Servicio de Hematología, Sanatorio Municipal Dr. Julio Méndez; Argentina  
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Fil: Cabrejo, María del Rosario. Servicio de Hematología, Sanatorio Municipal Dr. Julio Méndez; Argentina  
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Fil: Bezares, Raimundo F.. Servicio de Hematología, Hospital Municipal Dr. Teodoro Alvarez; Argentina  
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Fil: Trevani, Analía Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina; Argentina  
dc.description.fil
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.journal.title
Cancer Immunology Immunotherapy  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00262-016-1921-7  
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info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00262-016-1921-7