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Artículo

Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs)

Podaza, Enrique ArturoIcon ; Sabbione, FlorenciaIcon ; Risnik, Denise MarielIcon ; Borge, MercedesIcon ; Almejún, María BelénIcon ; Colado, AnaIcon ; Fernández Grecco, Horacio; Cabrejo, María del Rosario; Bezares, Raimundo F.; Trevani, Analía SilvinaIcon ; Gamberale, RominaIcon ; Giordano, Mirta NildaIcon
Fecha de publicación: 28/10/2016
Editorial: Springer
Revista: Cancer Immunology Immunotherapy
ISSN: 0340-7004
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Chronic lymphocytic leukemia (CLL) is characterized by immune defects that contribute to a high rate of infections and autoimmune cytopenias. Neutrophils are the first line of innate immunity and respond to pathogens through multiple mechanisms, including the release of neutrophil extracellular traps (NETs). These web-like structures composed of DNA, histones, and granular proteins are also produced under sterile conditions and play important roles in thrombosis and autoimmune disorders. Here we show that neutrophils from CLL patients are more prone to release NETs compared to those from age-matched healthy donors (HD). Increased generation of NETs was not due to higher levels of elastase, myeloperoxidase, or reactive oxygen species production. Instead, we found that plasma from CLL patients was able to prime neutrophils from HD to generate higher amounts of NETs upon activation. Plasmatic IL-8 was involved in the priming effect since its depletion reduced plasma capacity to enhance NETs release. Finally, we found that culture with NETs delayed spontaneous apoptosis and increased the expression of activation markers on leukemic B cells. Our study provides new insights into the immune dysregulation in CLL and suggests that the chronic inflammatory environment typical of CLL probably underlies this inappropriate neutrophil priming.
Palabras clave: CHRONIC LYMPHOCYTIC LEUKEMIA , INFECTIONS , INTERLEUKIN 8 (IL-8) , NEUTROPHIL , NEUTROPHIL EXTRACELLULAR TRAPS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/128605
DOI: http://dx.doi.org/10.1007/s00262-016-1921-7
URL: https://link.springer.com/article/10.1007/s00262-016-1921-7
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Citación
Podaza, Enrique Arturo; Sabbione, Florencia; Risnik, Denise Mariel; Borge, Mercedes; Almejún, María Belén; et al.; Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs); Springer; Cancer Immunology Immunotherapy; 66; 1; 28-10-2016; 77-89
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