Artículo

Isl1 is required for multiple aspects of motor neuron development

Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo MarcosIcon ; Liu, Yali; Zhuang, Tao; Chen, Yihan; Pfaff, Samuel L; Evans, Sylvia M; Sun, Yunfu
Fecha de publicación: 05/2011
Editorial: Elsevier
Revista: Molecular And Cellular Neurosciences.
ISSN: 1044-7431
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
Palabras clave: Motoneuron , Development , Spinal Cord , Specification
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/12808
URL: http://www.sciencedirect.com/science/article/pii/S1044743111000923
DOI: http://dx.doi.org/10.1016/j.mcn.2011.04.007
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo Marcos; Liu, Yali; et al.; Isl1 is required for multiple aspects of motor neuron development; Elsevier; Molecular And Cellular Neurosciences.; 47; 3; 5-2011; 215-222
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