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dc.contributor.author
Liang, Xingqun
dc.contributor.author
Song, Mi Ryoung
dc.contributor.author
Xu, ZengGuang
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Lanuza, Guillermo Marcos
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Liu, Yali
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Zhuang, Tao
dc.contributor.author
Chen, Yihan
dc.contributor.author
Pfaff, Samuel L
dc.contributor.author
Evans, Sylvia M
dc.contributor.author
Sun, Yunfu
dc.date.available
2017-02-09T18:58:28Z
dc.date.issued
2011-05
dc.identifier.citation
Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo Marcos; Liu, Yali; et al.; Isl1 is required for multiple aspects of motor neuron development; Elsevier; Molecular And Cellular Neurosciences.; 47; 3; 5-2011; 215-222
dc.identifier.issn
1044-7431
dc.identifier.uri
http://hdl.handle.net/11336/12808
dc.description.abstract
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Motoneuron
dc.subject
Development
dc.subject
Spinal Cord
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Specification
dc.subject.classification
Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Isl1 is required for multiple aspects of motor neuron development
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-07T13:52:10Z
dc.journal.volume
47
dc.journal.number
3
dc.journal.pagination
215-222
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Liang, Xingqun. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados Unidos
dc.description.fil
Fil: Song, Mi Ryoung. School of Life Sciences Gwangju Institute of Science and Technology. Bioimaging Research Center and Cell Dynamics Research Center; Corea del Sur
dc.description.fil
Fil: Xu, ZengGuang. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
dc.description.fil
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
dc.description.fil
Fil: Liu, Yali. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
dc.description.fil
Fil: Zhuang, Tao. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
dc.description.fil
Fil: Chen, Yihan. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
dc.description.fil
Fil: Pfaff, Samuel L. The Salk Institute. Gene Expression Laboratory; Estados Unidos
dc.description.fil
Fil: Evans, Sylvia M. Institute of Science and Technology; Corea del Sur. University Of California At San Diego; Estados Unidos
dc.description.fil
Fil: Sun, Yunfu. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados Unidos
dc.journal.title
Molecular And Cellular Neurosciences.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1044743111000923
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mcn.2011.04.007
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