Artículo
Platelet TLR4 at the crossroads of thrombosis and the innate immune response
Fecha de publicación:
04/12/2018
Editorial:
Federation of American Societies for Experimental Biology
Revista:
Journal of Leukocyte Biology
ISSN:
0741-5400
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
Palabras clave:
HMGB-1
,
LPS
,
NETS
,
PLATELETS
,
SEPSIS
,
THROMBOSIS
,
TLRS
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Identificadores
Colecciones
Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Schattner, Mirta Ana; Platelet TLR4 at the crossroads of thrombosis and the innate immune response; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 105; 5; 4-12-2018; 873-880
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