Artículo

Platelet TLR4 at the crossroads of thrombosis and the innate immune response

Schattner, Mirta AnaIcon
Fecha de publicación: 04/12/2018
Editorial: Federation of American Societies for Experimental Biology
Revista: Journal of Leukocyte Biology
ISSN: 0741-5400
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
Palabras clave: HMGB-1 , LPS , NETS , PLATELETS , SEPSIS , THROMBOSIS , TLRS
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/127868
URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.MR0618-213R
DOI: http://dx.doi.org/10.1002/JLB.MR0618-213R
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Citación
Schattner, Mirta Ana; Platelet TLR4 at the crossroads of thrombosis and the innate immune response; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 105; 5; 4-12-2018; 873-880
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