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dc.contributor.author
del Carmen, Silvina Andrea
dc.contributor.author
Leblanc, Jean Guy Joseph
dc.contributor.author
de Moreno, Maria Alejandra
dc.contributor.other
Leblanc, Jean Guy Joseph
dc.contributor.other
de Moreno, Maria Alejandra
dc.date.available
2021-03-03T18:29:47Z
dc.date.issued
2013
dc.identifier.citation
del Carmen, Silvina Andrea; Leblanc, Jean Guy Joseph; de Moreno, Maria Alejandra; Use of probiotics in the treatment of crohn's disease; Nova Science Publishers; 2013; 289-307
dc.identifier.isbn
978-1-62618-583-8
dc.identifier.uri
http://hdl.handle.net/11336/127328
dc.description.abstract
Probiotics can be defined as live microorganisms which when administered in adequate amounts confer a health benefit on the host. Because of the numerous beneficial properties that have been attributed to Lactic Acid Bacteria (LAB), these are the most commonly used probiotic microorganisms. Several studies have shown that LAB possess therapeutic properties since they are able to prevent the development of some diseases as shown mostly using animal models for gastrointestinal disorders such as inflammatory bowel diseases (IBD), infections or cancer. Some of the proposed mechanisms of action that account for the beneficial effects of these microorganisms in the course of IBD such as Crohn´s disease and ulcerative colitis includes: changes in the gut microbiota, stabilization of the intestine´s permeability barrier, regulation of the host immune responses and reduction of the oxidative stress due to their antioxidant enzyme production. Probiotic microorganisms, including strains of lactobacilli, lactococci, enterococci, Escherichia coli, bifidobacteria and Saccharomyces, favorably influence the course of experimental colitis in animal models or even in human clinical trials and can potentiate conventional treatments and reduce their side effects. The use of experimental animal models has proven useful in the study of IBD and is a necessary step in testing probiotic administration before launching clinical trials since not all bacterial species have equal activities in promoting or reducing intestinal inflammation. The present chapter will present some examples of studies using animal models and human clinical trials where probiotics were shown to be effective in the prevention or treatment of IBD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nova Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LACTIC ACIDS BACTERIA
dc.subject
PROBIOTICS
dc.subject
INFLAMMATORY BOWEL DISEASES
dc.subject
IMMUNE REGULATION
dc.subject
CROHN'S DISEASE
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Use of probiotics in the treatment of crohn's disease
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-09-02T20:18:28Z
dc.journal.pagination
289-307
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hauppauge
dc.description.fil
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://novapublishers.com/shop/crohns-disease-classification-diagnosis-and-treatment-options/
dc.conicet.paginas
355
dc.source.titulo
Crohn's disease: classification, diagnosis and treatment option
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