Artículo

2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones

Selvero, Marcel Manke; Ledesma, Gabriela NanciIcon ; Abram, Ulrich; Schulz Lang, Ernesto; Morel, Ademir Farias; Larghi, Enrique LeandroIcon
Fecha de publicación: 06/2020
Editorial: Elsevier Science SA
Revista: Journal of Fluorine Chemistry
ISSN: 0022-1139
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The unprecedented use of 2,2,2-trifluoroethanol as reaction solvent provided a facile and convenient access to symmetrically 3,3-disubstitued quinoline-2,4-diones in moderate to excellent yields and high regioselectivity, by reaction of 4-hydroxy-2-quinolones with electrophiles like methyl iodide, as well as benzyl and allyl bromides in the presence of K2CO3. Silver (I) oxide is required to increase the yield of the methylations.
Palabras clave: 2,2,2-TRIFLUOROETHANOL , 3,3-DISUBSTITUTED-QUINOLINE-2,4-DIONES , ALKYLATION , FLUORINATED SOLVENT , HETEROCYCLES
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/127158
URL: https://www.sciencedirect.com/science/article/abs/pii/S0022113920300713
DOI: http://dx.doi.org/10.1016/j.jfluchem.2020.109520
Colecciones
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
Selvero, Marcel Manke; Ledesma, Gabriela Nanci; Abram, Ulrich; Schulz Lang, Ernesto; Morel, Ademir Farias; et al.; 2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones; Elsevier Science SA; Journal of Fluorine Chemistry; 234; 6-2020; 1-7
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