Artículo

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; Gomes, Karina S.; Anderzhanova, Elmira; Pöhlmann, Max L.; Chang, Simon; Kolarz, Adam; Vogl, Annette M.; Dine, Julien; Metzger, Michael W.; Schmid, Bianca; Almada, Rafael C.; Ressler, Kerry J.; Wotjak, Carsten T.; Grinevich, Valery; Chen, Alon; Schmidt, Mathias V.; Wurst, Wolfgang; Refojo, DamianIcon ; Deussing, Jan M.
Fecha de publicación: 05/2018
Editorial: Nature Publishing Group
Revista: Nature Neuroscience.
ISSN: 1097-6256
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
Palabras clave: CRH , CRF , depression , behavior
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/125820
DOI: https://doi.org/10.1038/s41593-018-0151-z
URL: https://www.nature.com/articles/s41593-018-0151-z
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; et al.; Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety; Nature Publishing Group; Nature Neuroscience.; 21; 6; 5-2018; 803-807
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