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dc.contributor.author
Arrieta, Oscar
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Cardona, Andrés F.
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Bramuglia, Guillermo
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Cruz Rico, Graciela
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Corrales, Luis
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Martín, Claudio
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Imaz Olguín, Victoria
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Castillo, Omar
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Cuello, Mauricio
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Rojas Bilbao, Érica
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Casas, Gabriel
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Fernández, Cristina
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Arén Frontera, Osvaldo
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Denninghoff, Valeria Cecilia
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Recondo, Gonzalo
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Avilés Salas, Alejandro
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Mas Lopez, Luis Alberto
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Oblitas, George
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Rojas, Leonardo
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Piottante, Antonio
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Jiménez García, Ernesto
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Sánchez-Sosa, Sergio
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Sáenz Frias, Julia
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Lupera, Hernán
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Ramírez Tirado, Laura Alejandra
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Vargas, Carlos
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Carranza, Hernán
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Astudillo, Horacio
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Wills, Laura Beatriz
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Pichelbaur, Ernestina
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Raez, Luis E.
dc.date.available
2021-02-02T11:44:11Z
dc.date.issued
2019-04
dc.identifier.citation
Arrieta, Oscar; Cardona, Andrés F.; Bramuglia, Guillermo; Cruz Rico, Graciela; Corrales, Luis; et al.; Molecular Epidemiology of ALK Rearrangements in Advanced Lung Adenocarcinoma in Latin America; Karger; Oncology; 96; 4; 4-2019; 207-216
dc.identifier.issn
0030-2414
dc.identifier.uri
http://hdl.handle.net/11336/124441
dc.description.abstract
Objective: Latin American countries are heterogeneous in terms of lung cancer incidence and exposure to potential carcinogens. We evaluated the frequency and clinical characteristics of ALK rearrangements (ALKr) in Latin America. Methods: A total of 5,130 lung cancer patients from 10 Latin American countries were screened for inclusion. ALKr detection was performed by fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to assess method variability. Demographic and clinicopathologic characteristics were analyzed. Results: Among the 5,130 patients screened, 8.4% (n = 433) had nonevaluable FISH tests. Evaluable FISH analyses revealed positive ALKr in 6.8% (320/4,697) of the study population, which included patients from 9 countries. ALKr distribution for each country was: Mexico 7.6% (79/1,034), Colombia 4.1% (10/242), Argentina 6.0% (153/2,534), Costa Rica 9.5% (13/137), Panama 4.4% (5/114), Uruguay 5.4% (2/37), Chile 8.6% (16/185), Venezuela 8.9% (13/146), and Peru 10.8% (29/268). RT-PCR showed high positive (83.6%) and negative (99.7%) predictive values when compared to the gold standard FISH. In contrast, IHC only showed a high negative predictive value (94.6%). Conclusions: Although there is a clear country and continental variability in terms of ALKr frequency, this difference is not significant and the overall incidence of ALKr in Latin America does not differ from the rest of the world.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALK
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FISH
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LATIN AMERICA
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NON-SMALL-CELL LUNG CANCER
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REARRANGEMENTS
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Molecular Epidemiology of ALK Rearrangements in Advanced Lung Adenocarcinoma in Latin America
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-11T15:54:35Z
dc.journal.volume
96
dc.journal.number
4
dc.journal.pagination
207-216
dc.journal.pais
Suiza
dc.description.fil
Fil: Arrieta, Oscar. Instituto Nacional de Cancerologia; México
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Fil: Cardona, Andrés F.. Institute Of Oncology; Colombia
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Fil: Bramuglia, Guillermo. Foundation For Clinical And Applied Cancer Research; Colombia
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Fil: Cruz Rico, Graciela. Instituto Nacional de Cancerologia; México
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Fil: Corrales, Luis. Hospital San Juan de Dios; Costa Rica
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Fil: Martín, Claudio. Instituto Alexander Fleming.; Argentina
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Fil: Imaz Olguín, Victoria. Hospital ABC; Costa Rica
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Fil: Castillo, Omar. National Institute of Cancer; Panamá
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Fil: Cuello, Mauricio. Universidad de la República; Uruguay
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Fil: Rojas Bilbao, Érica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
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Fil: Casas, Gabriel. Hospital Aleman; Argentina
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Fil: Fernández, Cristina. Hospital Clínico de la Universidad de Chile; Chile
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Fil: Arén Frontera, Osvaldo. Hospital Clínico de la Universidad de Chile; Chile
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Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
dc.description.fil
Fil: Recondo, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
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Fil: Avilés Salas, Alejandro. Instituto Nacional de Cancerología; México
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Fil: Mas Lopez, Luis Alberto. Instituto Nacional de Enfermedades Neoplásicas; Perú
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Fil: Oblitas, George. Instituto Oncologico “Dr. Luis Razetti”; Venezuela
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Fil: Rojas, Leonardo. Hospital Universitario San Ignacio; Colombia
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Fil: Piottante, Antonio. Clínica las Condes; Chile
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Fil: Jiménez García, Ernesto. No especifíca;
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Fil: Sánchez-Sosa, Sergio. Hospital Ángeles de Puebla; México
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Fil: Sáenz Frias, Julia. Instituto Mexicano del Seguro Social; México
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Fil: Lupera, Hernán. Hospital Metropolitano; Ecuador
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Fil: Ramírez Tirado, Laura Alejandra. Instituto Nacional de Cancerología; México
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Fil: Vargas, Carlos. Institute of Oncology; Colombia
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Fil: Carranza, Hernán. Institute of Oncology; Colombia
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Fil: Astudillo, Horacio. No especifíca;
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Fil: Wills, Laura Beatriz. No especifíca;
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Fil: Pichelbaur, Ernestina. Universidad de Buenos Aires; Argentina
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Fil: Raez, Luis E.. Memorial Cancer Institute; Estados Unidos
dc.journal.title
Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/493733
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