Artículo
Molecular Epidemiology of ALK Rearrangements in Advanced Lung Adenocarcinoma in Latin America
Arrieta, Oscar; Cardona, Andrés F.; Bramuglia, Guillermo; Cruz Rico, Graciela; Corrales, Luis; Martín, Claudio; Imaz Olguín, Victoria; Castillo, Omar; Cuello, Mauricio; Rojas Bilbao, Érica; Casas, Gabriel; Fernández, Cristina; Arén Frontera, Osvaldo; Denninghoff, Valeria Cecilia
; Recondo, Gonzalo
; Avilés Salas, Alejandro; Mas Lopez, Luis Alberto; Oblitas, George; Rojas, Leonardo; Piottante, Antonio; Jiménez García, Ernesto; Sánchez-Sosa, Sergio; Sáenz Frias, Julia; Lupera, Hernán; Ramírez Tirado, Laura Alejandra; Vargas, Carlos; Carranza, Hernán; Astudillo, Horacio; Wills, Laura Beatriz; Pichelbaur, Ernestina; Raez, Luis E.
Fecha de publicación:
04/2019
Editorial:
Karger
Revista:
Oncology
ISSN:
0030-2414
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Objective: Latin American countries are heterogeneous in terms of lung cancer incidence and exposure to potential carcinogens. We evaluated the frequency and clinical characteristics of ALK rearrangements (ALKr) in Latin America. Methods: A total of 5,130 lung cancer patients from 10 Latin American countries were screened for inclusion. ALKr detection was performed by fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to assess method variability. Demographic and clinicopathologic characteristics were analyzed. Results: Among the 5,130 patients screened, 8.4% (n = 433) had nonevaluable FISH tests. Evaluable FISH analyses revealed positive ALKr in 6.8% (320/4,697) of the study population, which included patients from 9 countries. ALKr distribution for each country was: Mexico 7.6% (79/1,034), Colombia 4.1% (10/242), Argentina 6.0% (153/2,534), Costa Rica 9.5% (13/137), Panama 4.4% (5/114), Uruguay 5.4% (2/37), Chile 8.6% (16/185), Venezuela 8.9% (13/146), and Peru 10.8% (29/268). RT-PCR showed high positive (83.6%) and negative (99.7%) predictive values when compared to the gold standard FISH. In contrast, IHC only showed a high negative predictive value (94.6%). Conclusions: Although there is a clear country and continental variability in terms of ALKr frequency, this difference is not significant and the overall incidence of ALKr in Latin America does not differ from the rest of the world.
Palabras clave:
ALK
,
FISH
,
LATIN AMERICA
,
NON-SMALL-CELL LUNG CANCER
,
REARRANGEMENTS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CEMIC-CONICET)
Articulos de CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Articulos de CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Citación
Arrieta, Oscar; Cardona, Andrés F.; Bramuglia, Guillermo; Cruz Rico, Graciela; Corrales, Luis; et al.; Molecular Epidemiology of ALK Rearrangements in Advanced Lung Adenocarcinoma in Latin America; Karger; Oncology; 96; 4; 4-2019; 207-216
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