Artículo
Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases
Miraglia, Maria Cruz
; Scian, Romina
; Garcia Samartino, Clara
; Barrionuevo, Paula
; Baldi, Pablo Cesar
; Cassataro, Juliana
; Delpino, María Victoria
; Giambartolomei, Guillermo Hernan
; Rodríguez, Ana María
; Ibañez, Andres Esteban
; Coria, Lorena; Velasquez, Lis Noelia
Fecha de publicación:
04/2013
Editorial:
Biomed Central Ltd
Revista:
Journal Of Neuroinflammation
ISSN:
1742-2094
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to CNS damage. Matrix metalloproteinases (MMP) have been implicated in inflammatory tissue destruction in a range of pathological situations in the CNS. Increased MMP secretion is induced by pro-inflammatory cytokines in a variety of CNS diseases characterized by tissue-destructive pathology.
Palabras clave:
Brucella
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Miraglia, Maria Cruz; Scian, Romina; Garcia Samartino, Clara; Barrionuevo, Paula; Baldi, Pablo Cesar; et al.; Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases; Biomed Central Ltd; Journal Of Neuroinflammation; 10; 4-2013; 47-61
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