Artículo

Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases

Miraglia, Maria Cruz; Scian, RominaIcon ; Garcia Samartino, ClaraIcon ; Barrionuevo, PaulaIcon ; Baldi, Pablo CesarIcon ; Cassataro, JulianaIcon ; Delpino, María VictoriaIcon ; Giambartolomei, Guillermo HernanIcon ; Rodríguez, Ana MaríaIcon ; Ibañez, Andres EstebanIcon ; Coria, Lorena; Velasquez, Lis NoeliaIcon
Fecha de publicación: 04/2013
Editorial: Biomed Central Ltd
Revista: Journal Of Neuroinflammation
ISSN: 1742-2094
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to CNS damage. Matrix metalloproteinases (MMP) have been implicated in inflammatory tissue destruction in a range of pathological situations in the CNS. Increased MMP secretion is induced by pro-inflammatory cytokines in a variety of CNS diseases characterized by tissue-destructive pathology.

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http://www.jneuroinflammation.com/content/10/1/47
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Citación: Miraglia, Maria Cruz; Scian, Romina; Garcia Samartino, Clara; Barrionuevo, Paula; Baldi, Pablo Cesar; et al.; Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases; Biomed Central Ltd; Journal Of Neuroinflammation; 10; 4-2013; 47-61
URI: http://hdl.handle.net/11336/1240
 

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    Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO