Modified ribavirin analogues as antiviral agents against Junín virus

In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2–389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index.

Palabras clave: 1,2,3-TRIAZOLE RIBOSE CONJUGATES , ANTIVIRAL , CLICK CHEMISTRY , JUNÍN VIRUS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/123268

URL: https://linkinghub.elsevier.com/retrieve/pii/S0960894X18310254

DOI: http://dx.doi.org/10.1016/j.bmcl.2018.12.063

Colecciones

Articulos(IQUIBICEN) [853]
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES

Articulos(CIHIDECAR) [329]
Articulos de CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO

Articulos(OCA HOUSSAY) [1948]
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Citación

Contin, Mario Daniel; Sepúlveda, Claudia Soledad; Fascio, Mirta Liliana; Stortz, Carlos Arturo; Damonte, Elsa Beatriz; et al.; Modified ribavirin analogues as antiviral agents against Junín virus; Elsevier; Biorganic and Medicinal Chemistry Letters; 29; 4; 2-2019; 556-559

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