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dc.contributor.author
Francini, Flavio
dc.contributor.author
Schinella, Guillermo Raúl
dc.contributor.author
Ríos, José Luis
dc.date.available
2021-01-11T15:33:18Z
dc.date.issued
2019-07
dc.identifier.citation
Francini, Flavio; Schinella, Guillermo Raúl; Ríos, José Luis; Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 19; 11; 7-2019; 880-901
dc.identifier.issn
1389-5575
dc.identifier.uri
http://hdl.handle.net/11336/122232
dc.description.abstract
Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. In fact, some of them are standard drugs used for treatment of T2D, such as biguanides and thiazoli-dindiones. In this review, we compile the principal natural products that are activators of AMPK and their effect on glucose metabolism, which could make them candidates as future antidiabetic agents. Phenolics such as flavonoids and resveratrol, alkaloids such as berberine, and some saponins are potential natural activators of AMPK with a potential future as antidiabetic drugs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMPK
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ANTIDIABETIC DRUGS
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ANTIDIABETIC DRUGS
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MEDICINAL PLANTS
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NATURAL PRODUCTS
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TYPE 2 DIABETES MELLITUS
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-20T17:16:32Z
dc.journal.volume
19
dc.journal.number
11
dc.journal.pagination
880-901
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Oak Park
dc.description.fil
Fil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
dc.description.fil
Fil: Schinella, Guillermo Raúl. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
dc.description.fil
Fil: Ríos, José Luis. Universitat de Valencia Departamento de Farmacología; España
dc.journal.title
Mini-reviews In Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1389557519666181128120726
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/167810/article
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