Artículo
Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus
Fecha de publicación:
07/2019
Editorial:
Bentham Science Publishers
Revista:
Mini-reviews In Medicinal Chemistry
ISSN:
1389-5575
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. In fact, some of them are standard drugs used for treatment of T2D, such as biguanides and thiazoli-dindiones. In this review, we compile the principal natural products that are activators of AMPK and their effect on glucose metabolism, which could make them candidates as future antidiabetic agents. Phenolics such as flavonoids and resveratrol, alkaloids such as berberine, and some saponins are potential natural activators of AMPK with a potential future as antidiabetic drugs.
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Articulos(CENEXA)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Citación
Francini, Flavio; Schinella, Guillermo Raúl; Ríos, José Luis; Activation of AMPK by medicinal plants and natural products: Its role in type 2 diabetes mellitus; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 19; 11; 7-2019; 880-901
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