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dc.contributor.author
Diaz, Silvina Laura  
dc.contributor.author
Narboux Nême, Nicolas  
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Trowbridge, Sara  
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Scotto Lomassese, Sophie  
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Kleine Borgemann, Felix B.  
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Jessberger, Sebastian  
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Giros, Bruno  
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Maroteaux, Luc  
dc.contributor.author
Deneris, Evan  
dc.contributor.author
Gaspar, Patricia  
dc.date.available
2017-01-30T19:37:27Z  
dc.date.issued
2013-09  
dc.identifier.citation
Diaz, Silvina Laura; Narboux Nême, Nicolas; Trowbridge, Sara; Scotto Lomassese, Sophie; Kleine Borgemann, Felix B.; et al.; Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin; Wiley; European Journal Of Neuroscience; 38; 5; 9-2013; 2650-2658  
dc.identifier.issn
0953-816X  
dc.identifier.uri
http://hdl.handle.net/11336/12161  
dc.description.abstract
Increased adult neurogenesis is a major neurobiological correlate of the beneficial effects of antidepressants. Indeed, selective serotonin (5-HT) re-uptake inhibitors, which increase 5-HT transmission, enhance adult neurogenesis in the dentate gyrus (DG) of the hippocampus. However, the consequences of 5-HT depletion are still unclear as studies using neurotoxins that target serotonergic neurons reached contradictory conclusions on the role of 5-HT on DG cell proliferation. Here, we analysed two genetic models of 5-HT depletion, the Pet1-/- and the VMAT2f/f; SERTcre/+ mice, which have, respectively, 80 and 95% reductions in hippocampal 5-HT. In both models, we found unchanged cell proliferation of the neural precursors in the DG subgranular zone, whereas a significant increase in the survival of newborn neurons was noted 1 and 4 weeks after BrdU injections. This pro-survival trait was phenocopied pharmacologically with 5-HT synthesis inhibitor PCPA treatment in adults, indicating that this effect was not developmental. Furthermore, a 1-week administration of the 5-HT1A receptor agonist 8-OH-DPAT in Pet1-/- and PCPA-treated mice normalised hippocampal cell survival. Overall, our results indicate that constitutive 5-HT depletion does not alter the proliferation of neural precursors in the DG but promotes the survival of newborn cells, an effect which involves activation of postsynaptic 5-HT1A receptors. The role of 5-HT in selective neuronal elimination points to a new facet in its multiple effects in controlling neural circuit maturation.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
5-Hydroxytryptamine Depletion  
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Adult Neurogenesis  
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Genetic Mouse Models  
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Hippocampus  
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Bioquímica y Biología Molecular  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-11-24T17:19:23Z  
dc.journal.volume
38  
dc.journal.number
5  
dc.journal.pagination
2650-2658  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Paris  
dc.description.fil
Fil: Diaz, Silvina Laura. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Institut du Fer à Moulin; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "Profesor Eduardo de Robertis"; Argentina  
dc.description.fil
Fil: Narboux Nême, Nicolas. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Institut du Fer à Moulin; Francia  
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Fil: Trowbridge, Sara. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Institut du Fer à Moulin; Francia  
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Fil: Scotto Lomassese, Sophie. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Institut du Fer à Moulin; Francia  
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Fil: Kleine Borgemann, Felix B.. Universitat Zurich; Suiza  
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Fil: Jessberger, Sebastian. Universitat Zurich; Suiza  
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Fil: Giros, Bruno. Universite Pierre Et Marie Curie; Francia. Centre National de la Recherche Scientifique; Francia. Mc Gill University; Canadá  
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Fil: Maroteaux, Luc. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Institut du Fer à Moulin; Francia  
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Fil: Deneris, Evan. Case Western Reserve University; Estados Unidos  
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Fil: Gaspar, Patricia. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Institut du Fer à Moulin; Francia  
dc.journal.title
European Journal Of Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ejn.12297/abstract  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ejn.12297