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Artículo

Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin

Diaz, Silvina LauraIcon ; Narboux Nême, Nicolas; Trowbridge, Sara; Scotto Lomassese, Sophie; Kleine Borgemann, Felix B.; Jessberger, Sebastian; Giros, Bruno; Maroteaux, Luc; Deneris, Evan; Gaspar, Patricia
Fecha de publicación: 09/2013
Editorial: Wiley
Revista: European Journal Of Neuroscience
ISSN: 0953-816X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Increased adult neurogenesis is a major neurobiological correlate of the beneficial effects of antidepressants. Indeed, selective serotonin (5-HT) re-uptake inhibitors, which increase 5-HT transmission, enhance adult neurogenesis in the dentate gyrus (DG) of the hippocampus. However, the consequences of 5-HT depletion are still unclear as studies using neurotoxins that target serotonergic neurons reached contradictory conclusions on the role of 5-HT on DG cell proliferation. Here, we analysed two genetic models of 5-HT depletion, the Pet1-/- and the VMAT2f/f; SERTcre/+ mice, which have, respectively, 80 and 95% reductions in hippocampal 5-HT. In both models, we found unchanged cell proliferation of the neural precursors in the DG subgranular zone, whereas a significant increase in the survival of newborn neurons was noted 1 and 4 weeks after BrdU injections. This pro-survival trait was phenocopied pharmacologically with 5-HT synthesis inhibitor PCPA treatment in adults, indicating that this effect was not developmental. Furthermore, a 1-week administration of the 5-HT1A receptor agonist 8-OH-DPAT in Pet1-/- and PCPA-treated mice normalised hippocampal cell survival. Overall, our results indicate that constitutive 5-HT depletion does not alter the proliferation of neural precursors in the DG but promotes the survival of newborn cells, an effect which involves activation of postsynaptic 5-HT1A receptors. The role of 5-HT in selective neuronal elimination points to a new facet in its multiple effects in controlling neural circuit maturation.
Palabras clave: 5-Hydroxytryptamine Depletion , Adult Neurogenesis , Genetic Mouse Models , Hippocampus
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/12161
URL: http://onlinelibrary.wiley.com/doi/10.1111/ejn.12297/abstract
DOI: http://dx.doi.org/10.1111/ejn.12297
Colecciones
Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Citación
Diaz, Silvina Laura; Narboux Nême, Nicolas; Trowbridge, Sara; Scotto Lomassese, Sophie; Kleine Borgemann, Felix B.; et al.; Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin; Wiley; European Journal Of Neuroscience; 38; 5; 9-2013; 2650-2658
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