Artículo
Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi
Manarin, Romina
; Lamas, Maria Celina
; Bottasso, Emanuel; Serra, Esteban Carlos
; Revelli, Silvia Susana; Salomon, Claudio Javier
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Fecha de publicación:
02/2013
Editorial:
Elsevier Ireland
Revista:
Parasitology International
ISSN:
1383-5769
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8. million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100. mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment of this condition. Despite of the large number of pediatric patients infected, there are no commercial liquid dosage forms available to treat this trypanosomiasis. This work showed that novel benznidazole-water-polyethylene glycol 400 solutions are active against T. cruzi in a murine model of Chagas' disease. Present results constitute the first demonstration on the usefulness of benznidazole solutions in infected mice.
Palabras clave:
BENZNIDAZOLE
,
CHAGAS' DISEASE
,
IN VIVO STUDIES
,
SOLUBLE FORMULATION
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Identificadores
Colecciones
Articulos(IBR)
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Manarin, Romina; Lamas, Maria Celina; Bottasso, Emanuel; Serra, Esteban Carlos; Revelli, Silvia Susana; et al.; Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi; Elsevier Ireland; Parasitology International; 62; 1; 2-2013; 79-81
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