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dc.contributor.author
González Arbeláez, Luisa Fernanda
dc.contributor.author
Pérez Nuñez, Ignacio Adrián
dc.contributor.author
Mosca, Susana Maria
dc.date.available
2017-01-25T20:26:55Z
dc.date.issued
2013-09
dc.identifier.citation
González Arbeláez, Luisa Fernanda; Pérez Nuñez, Ignacio Adrián; Mosca, Susana Maria; Gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats; Hindawi Publishing Corporation; Journal Of Biomedicine And Biotechnology; 2013; 9-2013; 1-11; 317456
dc.identifier.issn
2314-6133
dc.identifier.uri
http://hdl.handle.net/11336/11946
dc.description.abstract
The aim of this study was to examine the effects of GSK-3 inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia (GI) and 1-hour reperfusion (R); PRE: a cycle of 5 min GI and 10 minutes of R prior to 45 min GI; POS: three cycles of 30 sec GI/30 sec R at the start of R. Other hearts received lithium chloride (LiCl) or indirubin-3 -monoxime,5-iodo-(IMI) as GSK-3 inhibitors. All interventions reduced the infarct size observed in IC group. The expressions of P-GSK-3 and P-Akt decreased in IC and were restored after PRE, POS, and GSK-3 inhibitors treatments. An increase of cytosolic MnSOD activity and lipid peroxidation and a decrease of GSH content observed in IC hearts were attenuated in PRE, POS, and LiCl or IMI treatments. An increase of P-GSK-3/VDAC physical association and a partial recovery of mitochondrial permeability were also detected after interventions. These data show that, in SHR hearts, GSK-3 inhibitors mimic the cardioprotection afforded by PRE and POS and suggest that a decrease in mitochondrial permeability mediated by P-GSK-3/VDAC interaction is a crucial event.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Gsk-3 Beta
dc.subject
Ischemic Preconditioning
dc.subject
Ischemic Postconditioning
dc.subject
Mitochondrial Swelling
dc.subject.classification
Otras Medicina Básica
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-25T13:57:17Z
dc.identifier.eissn
2314-6141
dc.journal.volume
2013
dc.journal.pagination
1-11; 317456
dc.journal.pais
Egipto
dc.journal.ciudad
El Cairo
dc.description.fil
Fil: González Arbeláez, Luisa Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Pérez Nuñez, Ignacio Adrián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Mosca, Susana Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.journal.title
Journal Of Biomedicine And Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2013/317456
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2013/317456/
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