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Artículo

Gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats

González Arbeláez, Luisa FernandaIcon ; Pérez Nuñez, Ignacio AdriánIcon ; Mosca, Susana MariaIcon
Fecha de publicación: 09/2013
Editorial: Hindawi Publishing Corporation
Revista: Journal Of Biomedicine And Biotechnology
ISSN: 2314-6133
e-ISSN: 2314-6141
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Básica

Resumen

The aim of this study was to examine the effects of GSK-3 inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia (GI) and 1-hour reperfusion (R); PRE: a cycle of 5 min GI and 10 minutes of R prior to 45 min GI; POS: three cycles of 30 sec GI/30 sec R at the start of R. Other hearts received lithium chloride (LiCl) or indirubin-3 -monoxime,5-iodo-(IMI) as GSK-3 inhibitors. All interventions reduced the infarct size observed in IC group. The expressions of P-GSK-3 and P-Akt decreased in IC and were restored after PRE, POS, and GSK-3 inhibitors treatments. An increase of cytosolic MnSOD activity and lipid peroxidation and a decrease of GSH content observed in IC hearts were attenuated in PRE, POS, and LiCl or IMI treatments. An increase of P-GSK-3/VDAC physical association and a partial recovery of mitochondrial permeability were also detected after interventions. These data show that, in SHR hearts, GSK-3 inhibitors mimic the cardioprotection afforded by PRE and POS and suggest that a decrease in mitochondrial permeability mediated by P-GSK-3/VDAC interaction is a crucial event.
Palabras clave: Gsk-3 Beta , Ischemic Preconditioning , Ischemic Postconditioning , Mitochondrial Swelling
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/11946
DOI: http://dx.doi.org/10.1155/2013/317456
URL: https://www.hindawi.com/journals/bmri/2013/317456/
Colecciones
Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
González Arbeláez, Luisa Fernanda; Pérez Nuñez, Ignacio Adrián; Mosca, Susana Maria; Gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats; Hindawi Publishing Corporation; Journal Of Biomedicine And Biotechnology; 2013; 9-2013; 1-11; 317456
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