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dc.contributor.author
Lascano, Elena C.
dc.contributor.author
Mattiazzi, Ramona Alicia
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dc.contributor.author
Negroni, Jorge A.
dc.date.available
2017-01-25T20:11:16Z
dc.date.issued
2015-03
dc.identifier.citation
Lascano, Elena C.; Mattiazzi, Ramona Alicia; Negroni, Jorge A.; Mathematical models: a precious tool for research in physiology; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 8; 2; 3-2015; 12-22
dc.identifier.uri
http://hdl.handle.net/11336/11934
dc.description.abstract
The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca2+ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Fisiología
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mathematical Models
dc.subject
Cardiac Myocyte
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Intracellular Calcium
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Multiscale Models
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Mathematical models: a precious tool for research in physiology
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-25T13:58:53Z
dc.identifier.eissn
1669-5410
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
12-22
dc.journal.pais
Argentina
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dc.journal.ciudad
La PLata
dc.description.fil
Fil: Lascano, Elena C.. Universidad Favaloro; Argentina
dc.description.fil
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Negroni, Jorge A.. Universidad Favaloro; Argentina
dc.journal.title
Physiological Mini Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/75
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