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dc.contributor.author
Wang, Fuqian  
dc.contributor.author
Sarotti, Ariel Marcelo  
dc.contributor.author
Jiang, Guangde  
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Huguet Tapia, José C.  
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Zheng, Shao Liang  
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Wu, Xiaohua  
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Li, Chunshun  
dc.contributor.author
Ding, Yousong  
dc.contributor.author
Cao, Shugeng  
dc.date.available
2020-11-10T16:59:31Z  
dc.date.issued
2020-06  
dc.identifier.citation
Wang, Fuqian; Sarotti, Ariel Marcelo; Jiang, Guangde; Huguet Tapia, José C.; Zheng, Shao Liang; et al.; Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242; American Chemical Society; Organic Letters; 22; 11; 6-2020; 4408-4412  
dc.identifier.issn
1523-7060  
dc.identifier.uri
http://hdl.handle.net/11336/118069  
dc.description.abstract
Waikikiamides A-C (1-3), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (4), notoamide F (5), and (-)-notoamide A (6), were isolated from Aspergillus sp. FM242. 1 and 2, bearing a hendecacyclic ring system, represent a novel skeleton. 3 features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds 1 and 3 exhibit antiproliferative activity with IC50 values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Chemical Society  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
WAIKKIKIAMIDES A-C  
dc.subject
DIKETOPIPERAZINE  
dc.subject
HAWAII FUNGAL  
dc.subject
DP4+  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-08-05T16:40:30Z  
dc.journal.volume
22  
dc.journal.number
11  
dc.journal.pagination
4408-4412  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Washington DC  
dc.description.fil
Fil: Wang, Fuqian. Wuhan Nº 1 Hospital; China. University of Hawaii at Hilo; Estados Unidos  
dc.description.fil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Jiang, Guangde. University of Florida; Estados Unidos  
dc.description.fil
Fil: Huguet Tapia, José C.. University of Florida; Estados Unidos  
dc.description.fil
Fil: Zheng, Shao Liang. Harvard University; Estados Unidos  
dc.description.fil
Fil: Wu, Xiaohua. University of Hawaii at Hilo; Estados Unidos  
dc.description.fil
Fil: Li, Chunshun. University of Hawaii at Hilo; Estados Unidos  
dc.description.fil
Fil: Ding, Yousong. University of Florida; Estados Unidos  
dc.description.fil
Fil: Cao, Shugeng. University Hawaii Cancer Research Center; Estados Unidos. University of Hawaii at Hilo; Estados Unidos  
dc.journal.title
Organic Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.orglett.0c01411  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.orglett.0c01411  

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