Artículo
Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242
Wang, Fuqian; Sarotti, Ariel Marcelo
; Jiang, Guangde; Huguet Tapia, José C.; Zheng, Shao Liang; Wu, Xiaohua; Li, Chunshun; Ding, Yousong; Cao, Shugeng
Fecha de publicación:
06/2020
Editorial:
American Chemical Society
Revista:
Organic Letters
ISSN:
1523-7060
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Waikikiamides A-C (1-3), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (4), notoamide F (5), and (-)-notoamide A (6), were isolated from Aspergillus sp. FM242. 1 and 2, bearing a hendecacyclic ring system, represent a novel skeleton. 3 features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds 1 and 3 exhibit antiproliferative activity with IC50 values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways.
Palabras clave:
WAIKKIKIAMIDES A-C
,
DIKETOPIPERAZINE
,
HAWAII FUNGAL
,
DP4+
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Licencia
Identificadores
Colecciones
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Wang, Fuqian; Sarotti, Ariel Marcelo; Jiang, Guangde; Huguet Tapia, José C.; Zheng, Shao Liang; et al.; Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242; American Chemical Society; Organic Letters; 22; 11; 6-2020; 4408-4412
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