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Artículo

Interaction between β‑Lactoglobuline and Weak Polyelectrolyte Chains: A Study Using Monte Carlo Simulation

Torres, Paola Beatriz; Quiroga, EvelinaIcon ; Ramirez Pastor, Antonio JoseIcon ; Boeris, ValeriaIcon ; Narambuena, Claudio FabianIcon
Fecha de publicación: 10/2019
Editorial: American Chemical Society
Revista: Journal of Physical Chemistry B
ISSN: 1520-6106
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Física de los Materiales Condensados

Resumen

Complexation between the β-lactoglobulin and a weak acid polyelectrolyte (PE) has been studied using Monte Carlo simulations. Different coarse-grained models were used to represent the system, and two different acidic constants were used on the PE model. The protein-PE interaction is quantified considering the average PE monomers adsorbed on the protein as a function of pH. A maximum in the interaction between macromolecules was found, which is explained as a function of the titration behavior of the β-lactoglobuline and weak PE. We also found that there was a direct relation between the pH range of monomers adsorbed and the change on dissociation profile of the protein and weak PE compared to isolated conditions. The complexation of protein-PE increased both the dissociation degree of the PE chain and the protein net charge. This benefits the monomer adsorption on the protein surface.
Palabras clave: β‑Lactoglobuline , Weak Polyelectrolyte Chains , Monte Carlo Simulation
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/116997
URL: https://pubs.acs.org/doi/10.1021/acs.jpcb.9b03276
DOI: http://dx.doi.org/10.1021/acs.jpcb.9b03276
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Articulos(INFAP)
Articulos de INST. DE FISICA APLICADA "DR. JORGE ANDRES ZGRABLICH"
Citación
Torres, Paola Beatriz; Quiroga, Evelina; Ramirez Pastor, Antonio Jose; Boeris, Valeria; Narambuena, Claudio Fabian; Interaction between β‑Lactoglobuline and Weak Polyelectrolyte Chains: A Study Using Monte Carlo Simulation; American Chemical Society; Journal of Physical Chemistry B; 123; 41; 10-2019; 8617-8627
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