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dc.contributor.author
Flores, Ana Claudia
dc.contributor.author
Marcos, C. Y.
dc.contributor.author
Paladino, Natalia
dc.contributor.author
Arruvito, Maria Lourdes
dc.contributor.author
Williams, F.
dc.contributor.author
Middleton, D.
dc.contributor.author
Fainboim, Leonardo
dc.date.available
2020-10-15T14:42:12Z
dc.date.issued
2007-12
dc.identifier.citation
Flores, Ana Claudia; Marcos, C. Y.; Paladino, Natalia; Arruvito, Maria Lourdes; Williams, F.; et al.; KIR receptors and HLA-C in the maintenance of pregnancy; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 112-113
dc.identifier.issn
0001-2815
dc.identifier.uri
http://hdl.handle.net/11336/115966
dc.description.abstract
The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
KIR immunoglobulin-like receptors
dc.subject
recurrent spontaneous abortions
dc.subject
natural killer cells;
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
KIR receptors and HLA-C in the maintenance of pregnancy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-10-14T21:25:01Z
dc.journal.volume
69
dc.journal.number
SUPPL. 1
dc.journal.pagination
112-113
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Marcos, C. Y.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina
dc.description.fil
Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina
dc.description.fil
Fil: Williams, F.. Belfast City Hospital; Irlanda
dc.description.fil
Fil: Middleton, D.. Belfast City Hospital; Irlanda
dc.description.fil
Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Tissue Antigens
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0039.2006.762_8.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1399-0039.2006.762_8.x
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