Artículo

KIR receptors and HLA-C in the maintenance of pregnancy

Flores, Ana ClaudiaIcon ; Marcos, C. Y.; Paladino, NataliaIcon ; Arruvito, Maria LourdesIcon ; Williams, F.; Middleton, D.; Fainboim, LeonardoIcon
Fecha de publicación: 12/2007
Editorial: Wiley Blackwell Publishing, Inc
Revista: Tissue Antigens
ISSN: 0001-2815
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.
Palabras clave: KIR immunoglobulin-like receptors , recurrent spontaneous abortions , natural killer cells;
 
Archivos asociados
Thumbnail
 
Tamaño: 79.91Kb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/115966
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0039.2006.762_8.x
DOI: http://dx.doi.org/10.1111/j.1399-0039.2006.762_8.x
Colecciones
Articulos(IBBM)
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Flores, Ana Claudia; Marcos, C. Y.; Paladino, Natalia; Arruvito, Maria Lourdes; Williams, F.; et al.; KIR receptors and HLA-C in the maintenance of pregnancy; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 112-113
Compartir
Altmétricas