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dc.contributor.author
Poretti, María Belén  
dc.contributor.author
Rask Andersen, Mathias  
dc.contributor.author
Kumar, Praveen  
dc.contributor.author
Rubiales, Susana Elizabeth  
dc.contributor.author
Fiol, Marta Haydee  
dc.contributor.author
Schiöth, Helgi B.  
dc.contributor.author
Carlini, Valeria Paola  
dc.date.available
2017-01-17T20:47:31Z  
dc.date.issued
2015-01  
dc.identifier.citation
Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; et al.; Ghrelin effects expression of several genes associated with depression-like behavior; Elsevier Inc; Progress Of Neuro-psychopharmacology And Biological Psychiatry; 56; 1-2015; 227–234  
dc.identifier.issn
0278-5846  
dc.identifier.uri
http://hdl.handle.net/11336/11510  
dc.description.abstract
Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ghrelin  
dc.subject
Olfatory Bulbectomy  
dc.subject
Opioid Receptors  
dc.subject
Vasopresin  
dc.subject.classification
Fisiología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Ghrelin effects expression of several genes associated with depression-like behavior  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-01-13T19:51:02Z  
dc.journal.volume
56  
dc.journal.pagination
227–234  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Poretti, María Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Rask Andersen, Mathias. Uppsala University; Suecia  
dc.description.fil
Fil: Kumar, Praveen. Uppsala University; Suecia  
dc.description.fil
Fil: Rubiales, Susana Elizabeth. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina  
dc.description.fil
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina  
dc.description.fil
Fil: Schiöth, Helgi B.. Uppsala University; Suecia  
dc.description.fil
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina  
dc.journal.title
Progress Of Neuro-psychopharmacology And Biological Psychiatry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pnpbp.2014.09.012  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584614001882