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Artículo

Ghrelin effects expression of several genes associated with depression-like behavior

Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana ElizabethIcon ; Fiol, Marta HaydeeIcon ; Schiöth, Helgi B.; Carlini, Valeria PaolaIcon
Fecha de publicación: 01/2015
Editorial: Elsevier Inc
Revista: Progress Of Neuro-psychopharmacology And Biological Psychiatry
ISSN: 0278-5846
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals.
Palabras clave: Ghrelin , Olfatory Bulbectomy , Opioid Receptors , Vasopresin
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/11510
DOI: http://dx.doi.org/10.1016/j.pnpbp.2014.09.012
URL: http://www.sciencedirect.com/science/article/pii/S0278584614001882
Colecciones
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; et al.; Ghrelin effects expression of several genes associated with depression-like behavior; Elsevier Inc; Progress Of Neuro-psychopharmacology And Biological Psychiatry; 56; 1-2015; 227–234
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