Artículo
Clinanthus microstephium, an Amaryllidaceae species with Cholinesterase Inhibitor Alkaloids: Structure−Activity analysis of Haemanthamine skeleton derivatives
Adessi Cofré, Tonino Graziano
; Borioni, José Luis
; Pigni, Natalia Belen
; Bastida, Jaume; Cavallaro, Valeria
; Murray, Ana Paula
; Puiatti, Marcelo
; Oberti, Juan Carlos María
; Leiva González, Segundo; Nicotra, Viviana Estela
; García, Manuela Emila
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Fecha de publicación:
05/2019
Editorial:
Wiley VCH Verlag
Revista:
Chemistry and Biodiversity
ISSN:
1612-1872
e-ISSN:
1612-1880
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Plants of the Amaryllidaceae family are well-known (not only) for their ornamental value but also for the alkaloids that they produce. In this report, the first phytochemical study of Clinanthus genus was carried out. The chemical composition of alkaloid fractions from Clinanthus microstephium was analyzed by GC/MS and NMR. Seven known compounds belonging to three structural types of Amaryllidaceae alkaloids were identified. An epimeric mixture of a haemanthamine-type compound (6-hydroxymaritidine) was tested as an inhibitor against acetyl- and butyrylcholinesterase enzymes (AChE and BChE, respectively), two enzymes relevant in the treatment of Alzheimer's disease, with good results. Structure–activity relationships through molecular docking studies with this alkaloid and other structurally related compounds were discussed.
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Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Citación
Adessi Cofré, Tonino Graziano; Borioni, José Luis; Pigni, Natalia Belen; Bastida, Jaume; Cavallaro, Valeria; et al.; Clinanthus microstephium, an Amaryllidaceae species with Cholinesterase Inhibitor Alkaloids: Structure−Activity analysis of Haemanthamine skeleton derivatives; Wiley VCH Verlag; Chemistry and Biodiversity; 16; 5; 5-2019
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