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dc.contributor.author
Meroño, Tomás
dc.contributor.author
Dauteuille, Carolane
dc.contributor.author
Tetzlaff, Walter Francisco
dc.contributor.author
Martín, Maximiliano
dc.contributor.author
Botta, Eliana Elizabeth
dc.contributor.author
Lhomme, Marie
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Saez, María Soledad
dc.contributor.author
Sorroche, Patricia Beatriz
dc.contributor.author
Boero, Laura Estela
dc.contributor.author
Arbelbide, Jorge
dc.contributor.author
Chapman, M. John
dc.contributor.author
Kontush, Anatol
dc.contributor.author
Brites, Fernando Daniel
dc.date.available
2020-09-15T20:56:39Z
dc.date.issued
2016-02
dc.identifier.citation
Meroño, Tomás; Dauteuille, Carolane; Tetzlaff, Walter Francisco; Martín, Maximiliano; Botta, Eliana Elizabeth; et al.; Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia; Elsevier; Clinical Nutrition (edinburgh, Lothian); 36; 2; 2-2016; 552-558
dc.identifier.issn
0261-5614
dc.identifier.uri
http://hdl.handle.net/11336/114064
dc.description.abstract
Background and aimsIron deficiency anemia (IDA) affects around 20?30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.MethodsTwo studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.ResultsIDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (−23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (−25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (−16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (−22% and +18%, respectively, p < 0.05).ConclusionIDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IRON DEFICIENCY ANEMIA
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HDL
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OXIDATIVE STRESS
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IRON
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LIPOPROTEIS
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PARAXONASE
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Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-08T14:01:14Z
dc.journal.volume
36
dc.journal.number
2
dc.journal.pagination
552-558
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Dauteuille, Carolane. Université Pierre et Marie Curie; Francia. Inserm; Francia
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Fil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Martín, Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Lhomme, Marie. Université Pierre et Marie Curie; Francia. Inserm; Francia
dc.description.fil
Fil: Saez, María Soledad. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Sorroche, Patricia Beatriz. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Arbelbide, Jorge. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
dc.description.fil
Fil: Chapman, M. John. Inserm; Francia
dc.description.fil
Fil: Kontush, Anatol. Inserm; Francia
dc.description.fil
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Clinical Nutrition (edinburgh, Lothian)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0261561416000595
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1016/j.clnu.2016.02.003
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