Artículo
Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia
Meroño, Tomás
; Dauteuille, Carolane; Tetzlaff, Walter Francisco
; Martín, Maximiliano; Botta, Eliana Elizabeth
; Lhomme, Marie; Saez, María Soledad; Sorroche, Patricia Beatriz; Boero, Laura Estela; Arbelbide, Jorge; Chapman, M. John; Kontush, Anatol; Brites, Fernando Daniel
Fecha de publicación:
02/2016
Editorial:
Elsevier
Revista:
Clinical Nutrition (edinburgh, Lothian)
ISSN:
0261-5614
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background and aimsIron deficiency anemia (IDA) affects around 20?30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.MethodsTwo studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.ResultsIDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (−23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (−25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (−16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (−22% and +18%, respectively, p < 0.05).ConclusionIDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA.
Palabras clave:
IRON DEFICIENCY ANEMIA
,
HDL
,
OXIDATIVE STRESS
,
IRON
,
LIPOPROTEIS
,
PARAXONASE
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Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Meroño, Tomás; Dauteuille, Carolane; Tetzlaff, Walter Francisco; Martín, Maximiliano; Botta, Eliana Elizabeth; et al.; Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia; Elsevier; Clinical Nutrition (edinburgh, Lothian); 36; 2; 2-2016; 552-558
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