Artículo
Does non-alcoholic fatty liver impair alterations of plasma lipoproteins and associated factors in metabolic syndrome?
Lucero, Diego Martín
; Zago, Valeria
; López, Graciela I.; Graffigna, Mabel Nora; López, Gustavo; Fainboim, Hugo; Miksztowicz, Verónica Julieta
; Gomez Rosso, Leonardo Adrián
; Belli, Susana Haydee; Levalle, Oscar Alberto; Berg, Gabriela Alicia
; Brites, Fernando Daniel
; Wigdorovitz de Wikinski, Regina Luisa; Schreier, Laura Ester
Fecha de publicación:
03/2011
Editorial:
Elsevier Science
Revista:
Clinica Chimica Acta
ISSN:
0009-8981
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Hepatic steatosis (HS) is closely associated to metabolic syndrome (MS). Both, VLDL-triglyceride oversecretion and intrahepatic deposits, can take place. We evaluated VLDL characteristics, CETP, hepatic lipase (HL), IDL and small dense LDL (sdLDL), in patients with HS associated to MS. Methods: We studied 3 groups matched by age and sex: 25 MS patients with HS (diagnosed by ultrasonography), 25 MS patients without HS and 25 healthy controls. Main measurements were: lipid profile, free fatty acids, VLDL composition, VLDL size by HPLC, CETP and HL activities, IDL-cholesterol and sdLDL-cholesterol. Results: Patients with HS presented higher triglyceride levels, HOMA-IR and free fatty acids, VLDL mass and VLDL-apoB (p < 0.05). No differences in VLDL composition were observed. MS groups presented higher proportion of large VLDL than controls (p < 0.05). HS group showed higher CETP than controls (p = 0.01) and almost higher than MS without HS (p = 0.06). CETP correlated with VLDL-cholesterol content, r = 0.48, p < 0.005. The increase in sdLDL-cholesterol correlated with CETP (r = 0.47) and HL (r = 0.56), independent of insulin resistance (p < 0.003). Conclusion: Despite intrahepatic fat, patients with HS secreted higher number of VLDL particles. CETP would have a remodeling action on VLDL in circulation, enriching it in cholesterol and also favoring, together with HL, the formation of sdLDL.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Lucero, Diego Martín; Zago, Valeria; López, Graciela I.; Graffigna, Mabel Nora; López, Gustavo; et al.; Does non-alcoholic fatty liver impair alterations of plasma lipoproteins and associated factors in metabolic syndrome?; Elsevier Science; Clinica Chimica Acta; 412; 7-8; 3-2011; 587-592
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